منابع مشابه
DNA replication checkpoint control.
The eukaryotic cell cycle comprises two critical phases, DNA replication (S phase) and the subsequent distribution of an equivalent genome to each of two daughter cells at mitosis (M phase). A signal transduction cascade called the replication checkpoint has evolved to ensure that M phase does not occur prior to the completion of S phase. The mitotic regulators targeted by this checkpoint have ...
متن کاملDNA replication checkpoint
Genomes are duplicated with a very high degree of accuracy every cell cycle. This challenging task is made more difficult by a variety of intrinsic and extrinsic agents that interrupt DNA replication. Replication forks can encounter many endogenous blocks such as transcription complexes and DNA repair machinery. External agents such as ultraviolet radiation, which produces a variety of base mod...
متن کاملDNA replication checkpoint control of Wee1 stability by vertebrate Hsl7
G2/M checkpoints prevent mitotic entry upon DNA damage or replication inhibition by targeting the Cdc2 regulators Cdc25 and Wee1. Although Wee1 protein stability is regulated by DNA-responsive checkpoints, the vertebrate pathways controlling Wee1 degradation have not been elucidated. In budding yeast, stability of the Wee1 homologue, Swe1, is controlled by a regulatory module consisting of the ...
متن کاملMDC1 collaborates with TopBP1 in DNA replication checkpoint control
Human TopBP1 is a major player in the control of the DNA replication checkpoint. In this study, we identified MDC1, a key checkpoint protein involved in the cellular response to DNA double-strand breaks, as a TopBP1-associated protein. The specific TopBP1-MDC1 interaction is mediated by the fifth BRCT domain of TopBP1 and the Ser-Asp-Thr (SDT) repeats of MDC1. In addition, we demonstrated that ...
متن کاملRecovery from the DNA Replication Checkpoint
Checkpoint recovery is integral to a successful checkpoint response. Checkpoint pathways monitor progress during cell division so that in the event of an error, the checkpoint is activated to block the cell cycle and activate repair pathways. Intrinsic to this process is that once repair has been achieved, the checkpoint signaling pathway is inactivated and cell cycle progression resumes. We us...
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ژورنال
عنوان ژورنال: Frontiers in Bioscience
سال: 1999
ISSN: 1093-9946,1093-4715
DOI: 10.2741/boddy